VCU news

By Lisa Crutchfield

A two-year research effort took Jeff Donowitz, M.D., half a world away in a search for answers to problems of malnutrition, stunted growth and oral vaccine failure seen in millions of children.

Now, armed with fresh data from the study, he’s ready to move forward, continuing his research on how overgrowth of bacteria in the small intestine is damaging the guts of children in low- and middle-income countries.

In 2014, Donowitz, an infectious diseases fellow in the Virginia Commonwealth University Department of Pediatrics, was one of just seven pediatricians in the U.S. chosen by the Association of Medical School Pediatric Department Chairs for the Pediatric Scientist Development Program. Over the past two years, he traveled frequently to Dhaka, Bangladesh, seeking to identify a viable cure.

Donowitz’s interest in international public health medicine was ignited by trips to Haiti when he was younger. Later, as he was looking for potential research topics, his interest was piqued by environmental enteropathy, a low-level chronic inflammation in the GI tract found in a large number of children living in unsanitary conditions.

“The effects of environmental enteropathy are very, very broad,” he said. “We have limited understanding of exactly what about it is affecting growth stunting, cognitive delays or oral vaccine failures, so that is partially what we are trying to figure out.”

Donowitz’s fellowship afforded him the opportunity to examine the issue under the mentorship of William Petri, M.D., Ph.D., the respected chief of Infectious Diseases and International Health at the University of Virginia. Bangladesh, Donowitz said, has world-class research facilities, including the International Centre for Diarrhoeal Disease Research, Bangladesh.

He hypothesized that small intestine bacterial overgrowth, also known as SIBO, could, in part, explain those problems in poor communities.

“When I started, there were only a few studies looking at SIBO in low-income countries, and most of them were just describing that it was there in large numbers,” Donowitz said. “That’s where I got into the field.”

During his two-year fellowship, Donowitz said his hypothesis proved credible. Overgrowth, which was found in one-in-six children tested, was indeed associated with inflammation in the GI tract.

But other findings surprised him.

“I had thought maybe SIBO was related to diarrheal disease but what we showed was that it’s really related to poor sanitation,” he said. "So what is it about poor sanitation that leads to overgrowth in these children?”

Donowitz has a hypothesis about that, which he is exploring in a new, larger study of 275 Bangladeshi children who he is following from birth to age 2. “We’ll be measuring SIBO at multiple time points,” he said. With that, he hopes to identify opportunities when treatment will be beneficial for the large numbers of children affected by SIBO.

Don’t be dissuaded by the first person who says there’s no money in it. 

“The nice thing about SIBO is that you can treat it with relatively low-cost antibiotics,” Donowitz said. “But the downside to that is antimicrobial resistance. The idea of giving antibiotics on a large scale to a lot of people is not very attractive.”

Not only is Donowitz advancing knowledge about childhood disease, he’s proved to himself that he can secure funding. That’s important, as this fall he’ll be submitting grant requests to continue his work.

Donowitz has a message to prospective researchers: “I think, a lot of times, young, smart people get put off of it because they hear that funding is hard to come by. Don’t be dissuaded by the first person who says there’s no money in it. It’s extremely rewarding.”

 

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